It is essential to know the values ​​and characteristics of the national culture of each country, since it plays an important role in the development and perpetuation of the country`s identity. In this respect, Iran, too, has certain aspects of public and national culture resulting from the nation's historical experience in facing with its political events and phenomena. The culture that bring challenges about countries, especially the western countries with the U.S on top which follow their goals against Iran`s nuclear program by determining economic sanctions. This article, by contriving theoritical support based on relative exclusion and identity, is seeking to answer this question that, "in recent years, what has caused Iran to persist on the continuation of its nuclear program, despite the economic pressures resulting from the sanctions?" The present research is done by descriptive and analytical method and collecting data from library and documentary studies, including books, scholarly articles, and the internet. The results show that religious dimensions of independence in Iran`s national culture has made the Islamic Republic of Iran emphasize on its rights, especially in the field of peaceful nuclear activities, and change the bad effects of the sanctions to the more self-reliance and further effectiveness in the international system level.